HitPredict

Interactor 1: MP2K6 (P52564)
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
Gene: MAP2K6

Interactor 2: NF2L2 (Q16236)
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)
Gene: NFE2L2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.603

Property	Details
Experiments	32911434
Identification Methods	two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, two hybrid array, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, fluorescence correlation spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002931 - response to ischemia GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 605
+	Hs
		681869 AKT1_HUMAN (12-334): 4.87e-124: 366: 22.05		NF2L2_HUMAN (1-605): 0: 560: 100.00
+	Hs
		972204 MP2K1_HUMAN (47-333): 9.74e-67: 216: 37.69		NF2L2_HUMAN (1-605): 0: 560: 100.00
+	Hs
		734942 MP2K2_HUMAN (47-328): 1.9e-64: 210: 36.89		NF2L2_HUMAN (1-605): 0: 560: 100.00
+	Hs
		401594 MP2K4_HUMAN (13-334): 2.42e-112: 333: 53.52		JUN_HUMAN (240-572): 5.59e-55: 191: 13.61
+	Hs
		160327 AURKA_HUMAN (5-323): 4.63e-112: 332: 23.44		JUN_HUMAN (240-572): 5.59e-55: 191: 13.61
+	Hs
		153068 MP2K7_HUMAN (4-333): 2.81e-108: 323: 41.84		JUN_HUMAN (240-572): 5.59e-55: 191: 13.61