HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	34079125, 19637314
Identification Methods	proximity labelling technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007266 - Rho protein signal transduction GO:0070062 - extracellular exosome GO:0098685 - Schaffer collateral - CA1 synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 204 Hs			1 196
+	Hs
		854769 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Mm
		925816 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10
+	Rn
		901290 GDIR1_RAT (1-204): 6.26e-117: 332: 97.06		RHOA_RAT (1-196): 3.27e-78: 233: 83.16
+	Hs
		854763 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545278 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436218 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		854771 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		854759 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		854760 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Mm
		892716 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC3_MOUSE (1-179): 1.15e-74: 224: 57.54
+	Hs
		854851 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		925561 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900840 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915920 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545279 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Mm
		892713 GDIR2_MOUSE (13-204): 1.25e-98: 285: 68.75		RAC3_MOUSE (1-179): 1.15e-74: 224: 57.54
+	Hs
		854852 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		951270 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		854847 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		894357 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49