HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	11368848, 35271311, 33513601
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0007266 - Rho protein signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 204 Hs			1 191
+	Hs
		854769 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Mm
		925816 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC1_MOUSE (1-191): 3.6e-82: 243: 71.88
+	Rn
		901290 GDIR1_RAT (1-204): 6.26e-117: 332: 97.06		RHOA_RAT (5-191): 4.18e-79: 235: 55.62
+	Hs
		545278 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		854760 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		854763 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		436218 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Hs
		854759 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Mm
		892716 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC3_MOUSE (1-177): 1.67e-75: 226: 72.88
+	At
		1105129 GDIR_ARATH (2-202): 4.35e-89: 263: 37.86		RAC3_ARATH (2-180): 7.36e-92: 268: 56.98
+	Hs
		854851 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		854852 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00
+	Hs
		925561 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		951270 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00
+	Hs
		545279 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		894357 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		900840 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Mm
		892713 GDIR2_MOUSE (13-204): 1.25e-98: 285: 68.75		RAC3_MOUSE (1-177): 1.67e-75: 226: 72.88
+	Hs
		854847 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Dm
		816393 Q9VW59_DROME (16-202): 2.38e-83: 247: 50.53		RHO1_DROME (5-191): 6.13e-75: 225: 56.68