HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	11809807, 11368848
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0001772 - immunological synapse GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 204 Hs			1 191
+	Hs
		436218 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		854767 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		854769 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Mm
		925816 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09
+	Hs
		854855 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00
+	Hs
		854760 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545278 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		854759 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Mm
		892716 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC3_MOUSE (2-171): 3.86e-72: 218: 41.81
+	Hs
		854771 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Rn
		901290 GDIR1_RAT (1-204): 6.26e-117: 332: 97.06		RHOA_RAT (6-191): 1.91e-71: 216: 39.90
+	Hs
		854763 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		915920 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		854851 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Mm
		892713 GDIR2_MOUSE (13-204): 1.25e-98: 285: 68.75		RAC3_MOUSE (2-171): 3.86e-72: 218: 41.81
+	Hs
		894357 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545279 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		854847 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		854852 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		900840 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38