HitPredict

Interactor 1: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Interactor 2: IRF9 (Q00978)
Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
Gene: IRF9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 33961781, 28514442, 8943351, 9242679, 21903422, 12954221, 17923090, 15668228, 15978943, 16195385, 10925286, 20943654, 21268015, 24065129
Identification Methods affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, electrophoretic mobility supershift assay, anti bait coimmunoprecipitation, cross-linking study
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains IRF-3~STAT_alpha
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024