HitPredict

Interactor 1: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.913

Property	Details
Experiments	28707474, 8848048, 28514442, 33961781
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	STAT2_C~zf-TAZ
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 851 Hs			1 2442
+	Hs
		786400 STAT1_HUMAN (1-728): 0: 879: 42.36		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		776769 STAT3_HUMAN (1-747): 0: 846: 37.47		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		855291 STAT2_HUMAN (1-851): 0: 1027: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		786628 STA5A_HUMAN (1-769): 0: 789: 24.67		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		849905 STA5B_HUMAN (1-768): 0: 774: 24.67		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		786494 STAT6_HUMAN (1-850): 0: 742: 24.19		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		786330 STAT1_HUMAN (1-728): 0: 879: 42.36		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		776665 STAT3_HUMAN (1-747): 0: 846: 37.47		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		786603 STA5A_HUMAN (1-769): 0: 789: 24.67		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Mm
		70905 STAT6_MOUSE (1-850): 0: 756: 24.10		EP300_MOUSE (1-2426): 0: 867: 53.61
+	Hs
		786478 STAT6_HUMAN (1-850): 0: 742: 24.19		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		776832 STAT3_HUMAN (1-747): 0: 846: 37.47		BRWD1_HUMAN (1053-1204): 5.63e-38: 159: 26.83
+	Hs
		170287 STAT3_HUMAN (1-747): 0: 846: 37.47		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		170290 STAT6_HUMAN (1-850): 0: 742: 24.19		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97