HitPredict

Interactor 1: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Interactor 2: UBP18 (Q9UMW8)
Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18)
Gene: USP18

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	28165510, 32092142, 35258551, 36646704, 31836668, 36753016
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0060339 - negative regulation of type I interferon-mediated signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 851 Hs			1 372
+	Hs
		786450 STAT1_HUMAN (1-728): 0: 879: 42.36		UBP22_HUMAN (31-370): 4.33e-105: 320: 20.53
+	Hs
		271048 STAT1_HUMAN (1-728): 0: 879: 42.36		UBP2_HUMAN (10-368): 1.33e-99: 309: 21.27
+	Mm
		1125412 Q99K94_MOUSE (1-701): 0: 867: 43.67		UBP22_MOUSE (31-370): 8.1e-105: 320: 20.53
+	Hs
		776858 STAT3_HUMAN (1-747): 0: 846: 37.47		UBP22_HUMAN (31-370): 4.33e-105: 320: 20.53
+	Mm
		786532 STAT3_MOUSE (1-747): 0: 846: 37.47		UBP22_MOUSE (31-370): 8.1e-105: 320: 20.53
+	Hs
		271058 STA5B_HUMAN (1-768): 0: 774: 24.67		UBP2_HUMAN (10-368): 1.33e-99: 309: 21.27
+	Hs
		786505 STAT6_HUMAN (1-850): 0: 742: 24.19		UBP18_HUMAN (1-372): 1.3e-110: 329: 100.00