HitPredict

Interactor 1: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26496610, 36089195
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1360 Hs			1 136
+	Hs
		855452 MSH6_HUMAN (1-1360): 0: 1486: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		111558 MSH6_HUMAN (1-1360): 0: 1486: 100.00		K7EK07_HUMAN (1-132): 7.81e-58: 177: 100.00
+	Hs
		828177 MSH6_HUMAN (1-1360): 0: 1486: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		594184 MSH3_HUMAN (173-1357): 0: 835: 22.16		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		594185 MSH3_HUMAN (173-1357): 0: 835: 22.16		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		794232 MSH2_HUMAN (393-1360): 0: 824: 21.88		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		794234 MSH2_HUMAN (393-1360): 0: 824: 21.88		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Sc
		902039 MSH6_YEAST (115-1347): 0: 821: 28.54		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		594175 MSH3_HUMAN (173-1357): 0: 835: 22.16		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Sc
		639281 MSH2_YEAST (408-1354): 0: 725: 20.96		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		935205 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952607 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086307 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1157224 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		331780 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		331787 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		331823 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		331833 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		828367 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		331748 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76