HitPredict

Interactor 1: EFNB2 (P52799)
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
Gene: EFNB2

Interactor 2: EPHB3 (P54753)
Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)
Gene: EPHB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 333 Hs			1 998
+	Mm
		856588 EFNB2_MOUSE (4-333): 0: 510: 96.97		EPHB3_MOUSE (35-998): 0: 1225: 97.00
+	Hs
		665565 EFNB2_HUMAN (1-333): 0: 517: 100.00		EPHB2_HUMAN (39-997): 0: 1214: 69.97
+	Mm
		856589 EFNB2_MOUSE (4-333): 0: 510: 96.97		EPHB2_MOUSE (39-998): 0: 1217: 70.10
+	Hs
		872403 EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23		EPHB3_HUMAN (1-998): 0: 1227: 100.00
+	Mm
		856293 EFNB1_MOUSE (9-333): 6.5e-164: 462: 54.23		EPHB3_MOUSE (35-998): 0: 1225: 97.00
+	Hs
		856508 EFNB2_HUMAN (1-333): 0: 517: 100.00		EPHA5_HUMAN (2-990): 0: 1169: 53.48
+	Hs
		665579 EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23		EPHB2_HUMAN (39-997): 0: 1214: 69.97
+	Rn
		454786 Q6P7B6_RAT (9-333): 3.46e-165: 465: 54.23		EPHB1_RAT (32-996): 0: 1209: 70.97
+	Mm
		856298 EFNB1_MOUSE (9-333): 6.5e-164: 462: 54.23		EPHB1_MOUSE (32-996): 0: 1210: 70.97
+	Hs
		856510 EFNB2_HUMAN (1-333): 0: 517: 100.00		EPHA4_HUMAN (17-993): 0: 1155: 56.95
+	Hs
		665381 EFNB2_HUMAN (1-333): 0: 517: 100.00		EPHA3_HUMAN (35-996): 0: 1154: 56.44
+	Mm
		856591 EFNB2_MOUSE (4-333): 0: 510: 96.97		EPHA4_MOUSE (17-993): 0: 1157: 56.95
+	Hs
		957840 EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23		EPHA7_HUMAN (15-998): 0: 1158: 54.18
+	Hs
		665390 EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23		EPHA3_HUMAN (35-996): 0: 1154: 56.44
+	Dr
		47564 EFNB2_DANRE (6-333): 2.04e-158: 448: 65.56		A0A8M9PHF0_DANRE (22-998): 0: 1148: 53.85
+	Dr
		140382 EFNB2_DANRE (6-333): 2.04e-158: 448: 65.56		EPHA3_DANRE (15-998): 0: 1116: 52.96
+	Hs
		856509 EFNB2_HUMAN (1-333): 0: 517: 100.00		EPHB4_HUMAN (25-991): 0: 1042: 59.02
+	Dr
		251122 EFNB2_DANRE (6-333): 2.04e-158: 448: 65.56		EPB4A_DANRE (21-996): 0: 1045: 57.03
+	Dr
		47540 EFNB2_DANRE (6-333): 2.04e-158: 448: 65.56		A0A8M3AP95_DANRE (25-640): 0: 740: 68.67
+	Hs
		674396 EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23		UFO_HUMAN (281-942): 6.02e-149: 467: 24.41