HitPredict

Interactor 1: EFNA5 (P52803)
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Gene: EFNA5

Interactor 2: EPHA6 (Q9UF33)
Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12)
Gene: EPHA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Hs			1 1036
+	Hs
		856606 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA7_HUMAN (9-1036): 0: 1192: 55.53
+	Mm
		139053 EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06		EPHA7_MOUSE (9-1036): 0: 1188: 55.73
+	Dr
		945416 EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74		Q5ZEW1_DANRE (17-1036): 0: 1208: 56.06
+	Hs
		856595 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA5_HUMAN (11-1028): 0: 1177: 56.86
+	Hs
		856597 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA4_HUMAN (15-1036): 0: 1176: 56.88
+	Hs
		665382 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Mm
		139054 EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06		Q8BRB1_MOUSE (18-1028): 0: 1166: 59.13
+	Hs
		856596 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHB1_HUMAN (33-1030): 0: 1155: 51.69
+	Mm
		139052 EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06		EPHB2_MOUSE (34-1034): 0: 1140: 51.29
+	Dr
		47566 EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74		A0A8M9PHF0_DANRE (16-1036): 0: 1166: 53.79
+	Dr
		140384 EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74		EPHA3_DANRE (7-1036): 0: 1155: 54.05
+	Hs
		856319 EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79		EPHA7_HUMAN (9-1036): 0: 1192: 55.53
+	Hs
		665459 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA8_HUMAN (34-1036): 0: 1095: 52.45
+	Hs
		665379 EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Hs
		665390 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Hs
		665579 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		EPHB2_HUMAN (34-1036): 0: 1138: 51.33
+	Hs
		665181 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA2_HUMAN (6-1036): 0: 1046: 45.57
+	Hs
		665179 EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79		EPHA2_HUMAN (6-1036): 0: 1046: 45.57
+	Hs
		522869 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		SRC_HUMAN (623-931): 3.42e-59: 214: 40.32
+	Hs
		522911 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		SRC_HUMAN (623-931): 3.42e-59: 214: 40.32