HitPredict

Interactor 1: CAZA1 (P52907)
F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
Gene: CAPZA1

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~F-actin_cap_A
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 375
+	Hs
		857090 CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		857101 CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		812976 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		812985 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		ACTG_HUMAN (1-375): 0: 604: 100.00
+	Hs
		812987 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		812988 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Dm
		862585 CAPZA_DROME (8-284): 3.9e-141: 400: 64.52		ACT3_DROME (2-375): 0: 596: 94.92