HitPredict

Interactor 1: NUP98 (P52948)
Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]
Gene: NUP98

Interactor 2: RAE1L (P78406)
mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41)
Gene: RAE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.988

Property	Details
Experiments	10209021, 888800000819, 21467841, 24927547, 26186194, 28514442, 27097363, 33961781, 18832153, 19615732, 20498086, 15851029, 17172455, 33097660, 35096974
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, molecular sieving, cosedimentation in solution, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Nup96~WD40
Common GO terms	GO:0003723 - RNA binding GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0006405 - RNA export from nucleus and 1 others more... GO:0006913 - nucleocytoplasmic transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1817 Hs			1 368
+	Mm
		1161320 NUP98_MOUSE (1-1816): 0: 1478: 91.63		RAE1L_MOUSE (17-368): 9.99e-93: 283: 99.15
+	Hs
		857957 NUP98_HUMAN (1-1817): 0: 1506: 100.00		WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75
+	Dm
		1358850 NUP98_DROME (9-1812): 0: 882: 27.29		WDS_DROME (261-367): 1.51e-22: 98.9: 13.89
+	Dm
		1362947 NUP98_DROME (9-1812): 0: 882: 27.29		RAE1_DROME (8-229): 1.73e-12: 69.6: 8.00
+	Ce
		106866 NUP98_CAEEL (53-1723): 0: 760: 21.38		BUB3_CAEEL (15-188): 1.75e-13: 72.6: 12.69
+	Hs
		834581 NU153_HUMAN (1-241): 3.42e-12: 74: 18.78		RAE1L_HUMAN (1-368): 5.99e-98: 296: 100.00
+	Hs
		727239 NU214_HUMAN (162-710): 1.58e-09: 65.4: 16.40		RAE1L_HUMAN (1-368): 5.99e-98: 296: 100.00
+	Xl
		1150105 Q6DCP4_XENLA (116-701): 4.67e-11: 69.8: 14.33		Q7ZZY7_XENLA (24-368): 4.09e-92: 281: 92.46
+	Dm
		113998 M9PB30_DROME (2-745): 1.85e-13: 78.6: 8.57		Q9W1T0_DROME (30-357): 5.75e-83: 257: 36.59
+	Hs
		903374 KMT2C_HUMAN (2-1031): 1.3e-48: 194: 8.35		WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75
+	Hs
		211213 KMT2C_HUMAN (2-1031): 1.3e-48: 194: 8.35		BUB3_HUMAN (16-188): 5.39e-14: 74: 13.71
+	Mm
		903669 KMT2C_MOUSE (119-812): 4.7e-23: 110: 9.58		WDR5_MOUSE (247-367): 7.8e-24: 102: 14.75
+	Sc
		767629 NU116_YEAST (3-603): 7.9e-21: 102: 16.28		GLE2_YEAST (11-231): 4.21e-14: 74.7: 10.76
+	Sc
		767628 NU100_YEAST (147-754): 1.94e-18: 94.4: 11.51		GLE2_YEAST (11-231): 4.21e-14: 74.7: 10.76
+	At
		1105208 NU98A_ARATH (237-780): 1.07e-15: 85.6: 11.21		RAE1_ARATH (11-200): 6.74e-16: 79.7: 11.17
+	Sc
		767617 NU159_YEAST (2-750): 1.85e-16: 88.3: 12.60		GLE2_YEAST (11-231): 4.21e-14: 74.7: 10.76
+	Hs
		1288235 P121A_HUMAN (2-326): 2.46e-09: 64.8: 14.42		SNR40_HUMAN (258-358): 1.55e-20: 93.1: 15.69
+	Sc
		541884 NSP1_YEAST (1-541): 6.79e-15: 82.5: 13.95		GLE2_YEAST (11-231): 4.21e-14: 74.7: 10.76
+	At
		1105232 NUP1_ARATH (1-432): 9.64e-13: 76: 15.70		RAE1_ARATH (11-200): 6.74e-16: 79.7: 11.17
+	Sc
		767621 NUP57_YEAST (1-164): 1.9e-10: 67.7: 27.06		GLE2_YEAST (11-231): 4.21e-14: 74.7: 10.76