HitPredict

Interactor 1: NUP98 (P52948)
Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]
Gene: NUP98

Interactor 2: SPAST (Q9UBP0)
Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)
Gene: SPAST

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031965 - nuclear membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1817 Hs			1 616
+	Sc
		698182 NU116_YEAST (3-603): 7.9e-21: 102: 16.28		AFG2_YEAST (9-615): 7.17e-118: 370: 21.37
+	Sc
		698181 NU100_YEAST (147-754): 1.94e-18: 94.4: 11.51		AFG2_YEAST (9-615): 7.17e-118: 370: 21.37
+	Sc
		698165 NU159_YEAST (2-750): 1.85e-16: 88.3: 12.60		AFG2_YEAST (9-615): 7.17e-118: 370: 21.37
+	Sc
		636672 NUP57_YEAST (1-164): 1.9e-10: 67.7: 27.06		CDC48_YEAST (323-616): 1.67e-79: 270: 30.92
+	Hs
		358491 CO1A1_HUMAN (230-764): 6.17e-14: 79.8: 8.79		TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86
+	Hs
		436026 CO1A2_HUMAN (524-808): 3.04e-13: 77.5: 6.67		TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86
+	Hs
		727229 NU214_HUMAN (162-710): 1.58e-09: 65.4: 16.40		TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86