HitPredict

Interactor 1: NKX25 (P52952)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: NKX2-5

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 324 Hs			1 217
+	Hs
		799074 NKX21_HUMAN (1-324): 6.22e-35: 132: 30.83		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		620240 PAX3_HUMAN (112-321): 5.64e-31: 123: 20.61		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924769 DLX4_HUMAN (36-246): 2.74e-31: 119: 25.35		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557634 NKX21_HUMAN (1-324): 6.22e-35: 132: 30.83		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337386 NKX21_HUMAN (1-324): 6.22e-35: 132: 30.83		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		557608 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		557609 PAX3_HUMAN (112-321): 5.64e-31: 123: 20.61		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337350 PAX3_HUMAN (112-321): 5.64e-31: 123: 20.61		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		557764 DLX4_HUMAN (36-246): 2.74e-31: 119: 25.35		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		941901 PITX1_HUMAN (74-322): 2.1e-30: 118: 19.12		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		337521 DLX4_HUMAN (36-246): 2.74e-31: 119: 25.35		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412077 NKX21_HUMAN (1-324): 6.22e-35: 132: 30.83		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		412020 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522846 NKX21_HUMAN (1-324): 6.22e-35: 132: 30.83		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		412021 PAX3_HUMAN (112-321): 5.64e-31: 123: 20.61		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Ce
		106223 VAB3_CAEEL (100-321): 1.84e-30: 121: 16.14		SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00
+	Hs
		522783 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		412292 DLX4_HUMAN (36-246): 2.74e-31: 119: 25.35		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522784 PAX3_HUMAN (112-321): 5.64e-31: 123: 20.61		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		523097 DLX4_HUMAN (36-246): 2.74e-31: 119: 25.35		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58