HitPredict

Interactor 1: NKX25 (P52952)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: NKX2-5

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35140242, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 324 Hs			1 772
+	Hs
		858093 NKX25_HUMAN (1-324): 9.3e-62: 201: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		620143 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Mm
		788279 NKX22_MOUSE (8-285): 5.09e-32: 122: 33.09		TLE3_MOUSE (1-772): 0: 580: 98.96
+	Hs
		724224 MSX2_HUMAN (59-253): 8.93e-36: 131: 27.54		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		620142 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		620144 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		641377 PAX6_HUMAN (83-321): 6.21e-31: 122: 17.89		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Mm
		623700 PAX3_MOUSE (112-321): 2.72e-31: 124: 20.61		TLE4_MOUSE (1-772): 6.16e-179: 533: 80.77
+	Hs
		724225 MSX2_HUMAN (59-253): 8.93e-36: 131: 27.54		TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10
+	Dm
		558357 VND_DROME (129-255): 4e-33: 131: 48.18		GROU_DROME (1-772): 4.17e-136: 421: 57.20
+	Hs
		724228 MSX2_HUMAN (59-253): 8.93e-36: 131: 27.54		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		620146 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Ce
		137685 HM30_CAEEL (66-246): 9.84e-33: 123: 24.34		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09
+	Ce
		137665 UNC4_CAEEL (80-296): 3.5e-32: 122: 18.27		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09
+	Mm
		1194602 NANOG_MOUSE (27-293): 2.18e-36: 134: 25.00		TBL1R_MOUSE (560-771): 3.94e-46: 174: 15.28
+	Mm
		1194713 NANOG_MOUSE (27-293): 2.18e-36: 134: 25.00		TBL1X_MOUSE (571-771): 5.49e-46: 174: 16.51
+	Hs
		799147 NKX21_HUMAN (1-324): 6.22e-35: 132: 30.83		TBL1R_HUMAN (571-771): 3.06e-46: 174: 15.07
+	Mm
		192307 ALX4_MOUSE (56-309): 3.64e-31: 122: 14.51		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66
+	Mm
		678773 HXA2_MOUSE (13-316): 4.54e-31: 122: 18.69		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66
+	Hs
		620138 PAX7_HUMAN (113-321): 3.33e-33: 129: 20.18		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12