HitPredict

Interactor 1: NKX25 (P52952)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: NKX2-5

Interactor 2: TBX5 (Q99593)
T-box transcription factor TBX5 (T-box protein 5)
Gene: TBX5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.825

The method score is based on:

Property Details
Experiments 11431700, 12845333
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Homeodomain~T-box
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003166 - bundle of His development
and 20 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 324
Hs

1 518
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024