HitPredict

Interactor 1: PRP43 (P53131)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (EC 3.6.4.13) (Helicase JA1)
Gene: PRP43

Interactor 2: PRP43 (P53131)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (EC 3.6.4.13) (Helicase JA1)
Gene: PRP43

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.61 1.00 0.786

The method score is based on:

Property Details
Experiments 28416566, 18467557
Identification Methods x-ray crystallography, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~DEAD, DEAD~HA2, DEAD~Helicase_C, HA2~Helicase_C, HA2~OB_NTP_bind, Helicase_C~Helicase_C, Helicase_C~OB_NTP_bind, OB_NTP_bind~OB_NTP_bind
Common GO terms GO:0000390 - spliceosomal complex disassembly
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
and 14 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 767
Sc

1 767
+ Hs
+ Sc
+ Hs
+ Sc
+ Hs
+ Ce
+ Hs
+ Ce
+ Sc
+ Ce
+ Hs
+ Sc
+ Hs
+ Hs

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Last updated: 15 Jul 2024