HitPredict

Interactor 1: MPC1 (P53157)
Mitochondrial pyruvate carrier 1 (MPC1) (Protein FMP37)
Gene: MPC1

Interactor 2: MPC3 (P53311)
Mitochondrial pyruvate carrier 3 (MPC3) (Protein FMP43)
Gene: MPC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	22628558, 24244496, 25672363, 30979775, 35278701
Identification Methods	tandem affinity purification, affinity chromatography technology, biochemical, cross-linking study, blue native page, anti tag coimmunoprecipitation, molecular sieving
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0006850 - mitochondrial pyruvate transmembrane transport GO:0050833 - pyruvate transmembrane transporter activity GO:0098800 - inner mitochondrial membrane protein complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 130 Sc			1 146
+	Sc
		756324 MPC2_YEAST (1-106): 7.89e-42: 136: 25.47		MPC3_YEAST (1-146): 8.59e-79: 231: 100.00
+	Sc
		861385 MPC3_YEAST (1-106): 3.12e-41: 135: 22.64		MPC3_YEAST (1-146): 8.59e-79: 231: 100.00
+	Sc
		756323 MPC1_YEAST (1-130): 8.83e-60: 181: 100.00		MPC2_YEAST (1-117): 3.55e-58: 178: 78.63
+	Sc
		859713 MPC1_YEAST (1-130): 8.83e-60: 181: 100.00		MPC1_YEAST (1-109): 1.33e-48: 154: 22.61
+	Sc
		756320 MPC2_YEAST (1-106): 7.89e-42: 136: 25.47		MPC2_YEAST (1-117): 3.55e-58: 178: 78.63
+	Hs
		316458 MPC1_HUMAN (8-106): 6.59e-45: 143: 52.53		MPC2_HUMAN (6-100): 3.82e-44: 142: 49.47
+	Hs
		316411 MPC1L_HUMAN (11-118): 1.96e-38: 127: 44.44		MPC2_HUMAN (6-100): 3.82e-44: 142: 49.47
+	Hs
		316405 MPC2_HUMAN (5-112): 7.79e-38: 126: 19.44		MPC2_HUMAN (6-100): 3.82e-44: 142: 49.47