HitPredict

Interactor 1: GYP2 (P53258)
GTPase-activating protein GYP2 (MAC1-dependent regulator) (Protein MIC1)
Gene: MDR1

Interactor 2: YPT6 (Q99260)
GTP-binding protein YPT6
Gene: YPT6

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.80	0.687

Property	Details
Experiments	11689439, 10559187
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RabGAP-TBC~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 950 Sc			1 215
+	Hs
		894747 TBC9B_HUMAN (14-853): 2.49e-153: 486: 22.30		RAB8A_HUMAN (11-215): 2.51e-89: 263: 39.02
+	Hs
		894727 TBC8B_HUMAN (7-882): 1.1e-153: 484: 21.41		RAB8A_HUMAN (11-215): 2.51e-89: 263: 39.02
+	Hs
		321281 TBCD8_HUMAN (7-877): 3.11e-147: 467: 22.22		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		234370 EVI5_HUMAN (162-847): 4.5e-117: 379: 18.13		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		234378 EVI5_HUMAN (162-847): 4.5e-117: 379: 18.13		RB11B_HUMAN (1-214): 3.37e-80: 240: 30.42
+	Hs
		914275 EVI5L_HUMAN (152-847): 5.28e-112: 365: 17.56		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		1079952 EVI5L_HUMAN (152-847): 5.28e-112: 365: 17.56		RB11B_HUMAN (1-214): 3.37e-80: 240: 30.42
+	Hs
		914482 RBGP1_HUMAN (85-723): 2.06e-106: 357: 15.64		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		592719 RBGP1_HUMAN (85-723): 2.06e-106: 357: 15.64		RAB6A_HUMAN (5-215): 3.69e-81: 242: 59.54
+	Dm
		185654 EVI5_DROME (137-875): 1.1e-103: 343: 18.72		RAB6_DROME (5-183): 3.4e-82: 244: 69.27
+	Dm
		185716 EVI5_DROME (137-875): 1.1e-103: 343: 18.72		O18335_DROME (2-214): 1.65e-80: 240: 30.52
+	Hs
		232698 TBCD4_HUMAN (18-627): 5.31e-91: 317: 19.10		RAB2B_HUMAN (7-214): 2.25e-80: 240: 32.41
+	Hs
		914176 TBCD1_HUMAN (18-594): 1.78e-88: 308: 17.61		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Os
		772871 Q5SMT0_ORYSJ (20-489): 1.03e-90: 305: 14.40		RIC2_ORYSJ (1-214): 3.56e-80: 240: 27.98
+	Sc
		1015456 MSB4_YEAST (211-492): 1.16e-81: 274: 26.79		YPT6_YEAST (1-215): 4.28e-83: 247: 100.00
+	Hs
		844684 SGSM3_HUMAN (167-779): 1.41e-114: 370: 17.27		RAB5C_HUMAN (4-196): 2.82e-45: 151: 38.00
+	Hs
		592434 SGSM3_HUMAN (167-779): 1.41e-114: 370: 17.27		RAB5A_HUMAN (4-213): 3.49e-44: 148: 37.14
+	Hs
		72915 B4DMS2_HUMAN (209-779): 1.69e-114: 365: 18.34		RAB5C_HUMAN (4-196): 2.82e-45: 151: 38.00
+	Hs
		895374 SGSM3_HUMAN (167-779): 1.41e-114: 370: 17.27		RAB5B_HUMAN (8-213): 6.68e-43: 145: 37.86
+	Dm
		185735 Q8IPP5_DROME (5-641): 1.15e-103: 354: 16.24		O18339_DROME (11-197): 3.78e-42: 143: 40.43