HitPredict

Interactor 1: SUCB (P53312)
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta)
Gene: LSC2

Interactor 2: SUCA (P53598)
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
Gene: LSC1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.908

The method score is based on:

Property Details
Experiments 37968396, 32051233, 16554755, 22940862, 16429126
Identification Methods affinity chromatography technology, cross-linking study, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-grasp_2~CoA_binding, ATP-grasp_2~Ligase_CoA, CoA_binding~Ligase_CoA, Ligase_CoA~Ligase_CoA
Common GO terms GO:0004775 - succinate-CoA ligase (ADP-forming) activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006099 - tricarboxylic acid cycle
GO:0006104 - succinyl-CoA metabolic process
and 2 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 427
Sc

1 329
+ Hs
+ Ss
+ Hs
+ Ec
+ Cj
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024