HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: CD20B (Q86Y33)
Cell division cycle protein 20 homolog B
Gene: CDC20B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0010997 - anaphase-promoting complex binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 519
+	Hs
		861879 PLK1_HUMAN (1-603): 0: 617: 100.00		FBXW7_HUMAN (117-512): 1.36e-71: 243: 13.58
+	Hs
		1205210 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		CD20B_HUMAN (1-519): 1.12e-118: 360: 100.00
+	Hs
		1281434 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		FBXW7_HUMAN (117-512): 1.36e-71: 243: 13.58
+	Hs
		861978 PLK1_HUMAN (1-603): 0: 617: 100.00		FZR1_HUMAN (60-262): 1.04e-10: 65.8: 5.91
+	Hs
		861722 PLK1_HUMAN (1-603): 0: 617: 100.00		CDC20_HUMAN (17-268): 4.18e-09: 60.8: 7.42
+	Dm
		854072 POLO_DROME (30-594): 6.97e-179: 520: 51.92		Q9W4H9_DROME (60-261): 4.47e-11: 67: 8.42
+	Sc
		693138 CDC5_YEAST (30-571): 1.47e-144: 436: 29.05		CDH1_YEAST (39-397): 5.53e-24: 107: 13.14
+	Hs
		682161 AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51		GBB1_HUMAN (304-518): 1.08e-19: 92: 15.14
+	Hs
		160697 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		FBXW7_HUMAN (117-512): 1.36e-71: 243: 13.58
+	Hs
		160853 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		FZR1_HUMAN (60-262): 1.04e-10: 65.8: 5.91
+	Hs
		160536 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		CDC20_HUMAN (17-268): 4.18e-09: 60.8: 7.42