Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: PLK3 (Q9H4B4)
Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)
Gene: PLK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.621

The method score is based on:

Property Details
Experiments 12548019
Identification Methods two hybrid
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, POLO_box~POLO_box
Common GO terms GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0004674 - protein serine/threonine kinase activity
and 10 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 603
Hs

1 646
+ Hs
+ Dr
+ Hs
+ Ce
+ Ce
+ Dm
+ Sc
+ At
+ At
+ At
+ Zm
+ Hs
+ At
+ At
+ At
+ Dm
+ At

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Last updated: 15 Jul 2024