HitPredict

Interactor 1: THO2 (P53552)
THO complex subunit 2 (Low dye-binding protein 5) (THO complex subunit RLR1) (Zinc-regulated gene 13 protein)
Gene: THO2

Interactor 2: TEX1 (P53851)
Protein TEX1 (Trex component 1)
Gene: TEX1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	11979277, 16554755, 16429126, 37968396, 22314234, 24244187, 14759368
Identification Methods	affinity chromatography technology, x-ray crystallography, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Thoc2~WD40, THOC2_N~WD40
Common GO terms	GO:0000346 - transcription export complex GO:0000445 - THO complex part of transcription export complex GO:0003729 - mRNA binding GO:0006368 - transcription elongation by RNA polymerase II GO:0006406 - mRNA export from nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1597 Sc			1 422
+	Hs
		1246350 THOC2_HUMAN (32-1589): 0: 1376: 16.89		THOC3_HUMAN (13-317): 9.03e-29: 117: 10.13
+	Dm
		1367496 Q9VQ76_DROME (24-1579): 0: 1265: 15.64		Q9VHT2_DROME (189-358): 7.14e-20: 91.7: 12.28
+	At
		96053 THOC2_ARATH (27-1583): 0: 1195: 18.53		THOC3_ARATH (143-359): 8.24e-25: 105: 10.04
+	Hs
		1309964 BUD13_HUMAN (1236-1593): 8.33e-19: 94.6: 9.54		NLE1_HUMAN (88-408): 1.49e-73: 240: 11.41
+	Hs
		1132750 ZC3HD_HUMAN (1174-1597): 6.38e-13: 76.5: 10.38		NLE1_HUMAN (88-408): 1.49e-73: 240: 11.41
+	Hs
		1302927 MINT_HUMAN (1152-1597): 3.88e-09: 64.2: 10.00		NLE1_HUMAN (88-408): 1.49e-73: 240: 11.41
+	Hs
		1288263 SCAFB_HUMAN (1092-1575): 8.81e-25: 115: 11.00		SNR40_HUMAN (3-186): 1e-30: 122: 14.89
+	Hs
		920992 ANR11_HUMAN (1192-1596): 2.95e-19: 97.3: 10.18		GBB1_HUMAN (178-420): 6.28e-37: 139: 11.34
+	Hs
		1133288 RBM20_HUMAN (1081-1490): 3.76e-24: 113: 7.30		SNR40_HUMAN (3-186): 1e-30: 122: 14.89
+	Hs
		1288271 BUD13_HUMAN (1236-1593): 8.33e-19: 94.6: 9.54		SNR40_HUMAN (3-186): 1e-30: 122: 14.89
+	Hs
		1221289 RB12B_HUMAN (1191-1574): 8.45e-18: 91.9: 10.34		SNR40_HUMAN (3-186): 1e-30: 122: 14.89
+	Hs
		920939 ANK2_HUMAN (1213-1588): 2.66e-10: 68: 11.02		GBB1_HUMAN (178-420): 6.28e-37: 139: 11.34
+	Hs
		1132721 ZC3HD_HUMAN (1174-1597): 6.38e-13: 76.5: 10.38		SNR40_HUMAN (3-186): 1e-30: 122: 14.89
+	Hs
		1288258 MINT_HUMAN (1152-1597): 3.88e-09: 64.2: 10.00		SNR40_HUMAN (3-186): 1e-30: 122: 14.89
+	Hs
		132301 CAC1A_HUMAN (1161-1592): 1.2e-17: 91.9: 9.96		GBB2_HUMAN (284-408): 6.96e-15: 77.1: 10.16
+	Hs
		903218 EIF3A_HUMAN (1114-1597): 2.77e-15: 84.2: 9.72		WDR5_HUMAN (2-91): 2.94e-14: 75.2: 16.67