Interactor 1: PGTB1 (P53610)
Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)
Gene: Pggt1b

Interactor 2: FNTA (Q04631)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
Gene: FNTA

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 18957540, 15248757
Identification Methods pull down, x-ray crystallography
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PPTA~Prenyltrans
Common GO terms GO:0004661 - protein geranylgeranyltransferase activity
GO:0004662 - CAAX-protein geranylgeranyltransferase activity
GO:0005953 - CAAX-protein geranylgeranyltransferase complex
GO:0008284 - positive regulation of cell population proliferation
GO:0018344 - protein geranylgeranylation
and 3 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 377
Rn

1 377
+ Hs
+ Hs
+ Rn
+ Ce
+ At
+ Ce
+ Dm
+ Sp
+ Hs
+ Sp
+ Sc
+ Rn
+ Sc
+ Dm
+ Sc
+ Dm
+ Hs
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024