HitPredict

Interactor 1: COPB (P53618)
Coatomer subunit beta (Beta-coat protein) (Beta-COP)
Gene: COPB1

Interactor 2: COPA (P53621)
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]
Gene: COPA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.940

The method score is based on:

Property	Details
Experiments	8940050, 37071682, 9751720, 10921873, 35271311, 35235311
Identification Methods	affinity chromatography technology, cross-linking study, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Adaptin_N~Coatomer_WDAD, Coatamer_beta_C~Coatomer_WDAD, Coatomer_WDAD~Coatomer_b_Cpla
Common GO terms	GO:0000139 - Golgi membrane GO:0005198 - structural molecule activity GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0006886 - intracellular protein transport and 5 others more... GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006891 - intra-Golgi vesicle-mediated transport GO:0016020 - membrane GO:0030126 - COPI vesicle coat GO:0030133 - transport vesicle
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	953
Hs

1	1224

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024