HitPredict - High confidence protein-protein interactions

Interactor 1: CATC (P53634)
Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]
Gene: CTSC

Interactor 2: CATC (P53634)
Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]
Gene: CTSC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CathepsinC_exc~CathepsinC_exc, CathepsinC_exc~Peptidase_C1, Peptidase_C1~Peptidase_C1
Common GO terms	GO:0001913 - T cell mediated cytotoxicity GO:0004197 - cysteine-type endopeptidase activity GO:0004252 - serine-type endopeptidase activity GO:0005576 - extracellular region GO:0005615 - extracellular space and 24 others more... GO:0005654 - nucleoplasm GO:0005764 - lysosome GO:0005788 - endoplasmic reticulum lumen GO:0005813 - centrosome GO:0006508 - proteolysis GO:0006955 - immune response GO:0008234 - cysteine-type peptidase activity GO:0008239 - dipeptidyl-peptidase activity GO:0016020 - membrane GO:0016505 - peptidase activator activity involved in apoptotic process GO:0019902 - phosphatase binding GO:0030134 - COPII-coated ER to Golgi transport vesicle GO:0031404 - chloride ion binding GO:0031642 - negative regulation of myelination GO:0033116 - endoplasmic reticulum-Golgi intermediate compartment membrane GO:0035578 - azurophil granule lumen GO:0043231 - intracellular membrane-bounded organelle GO:0051087 - protein-folding chaperone binding GO:0051603 - proteolysis involved in protein catabolic process GO:0062023 - collagen-containing extracellular matrix GO:0070062 - extracellular exosome GO:1903052 - positive regulation of proteolysis involved in protein catabolic process GO:1903980 - positive regulation of microglial cell activation GO:2001235 - positive regulation of apoptotic signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	463
Hs

1	463

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Last updated: 15 Jul 2024