HitPredict

Interactor 1: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	12577067
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 217
+	Hs
		924986 AP4S1_HUMAN (1-141): 1.71e-48: 154: 43.26		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924775 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411808 AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337527 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		69211 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46
+	Hs
		864110 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		1287515 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		864076 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		1078888 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00