HitPredict

Interactor 1: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 142 Hs			1 949
+	Hs
		880409 AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		903682 AP1S1_HUMAN (1-142): 2.51e-51: 161: 44.37		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		1014066 AP1S3_HUMAN (1-142): 1.49e-49: 157: 42.96		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		1014107 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		880408 AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		903681 AP1S1_HUMAN (1-142): 2.51e-51: 161: 44.37		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		925978 AP1S3_HUMAN (1-142): 1.49e-49: 157: 42.96		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		926066 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		212611 AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		212614 AP1S1_HUMAN (1-142): 2.51e-51: 161: 44.37		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		1032730 AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54		AP3B2_HUMAN (6-627): 2.76e-180: 553: 27.47
+	Hs
		212659 AP1S3_HUMAN (1-142): 1.49e-49: 157: 42.96		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Mm
		612130 AP1M1_MOUSE (2-137): 3.79e-44: 151: 14.71		AP1G1_MOUSE (12-822): 0: 557: 17.17
+	Hs
		212676 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		212662 AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Dm
		1362881 Q9VCF4_DROME (1-142): 8.02e-53: 165: 45.78		Q9W388_DROME (12-822): 3.54e-161: 499: 14.08
+	Dm
		1182762 Q9VCF4_DROME (1-142): 8.02e-53: 165: 45.78		Q7KVR8_DROME (12-822): 3.54e-159: 495: 14.02
+	Hs
		120009 AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54		AP3B1_HUMAN (6-620): 6.51e-156: 489: 27.73
+	Hs
		119942 AP3S2_HUMAN (1-142): 4.07e-49: 157: 37.84		AP3B1_HUMAN (6-620): 6.51e-156: 489: 27.73
+	Hs
		1377945 AP4S1_HUMAN (1-141): 1.71e-48: 154: 43.26		AP4B1_HUMAN (15-629): 1.97e-153: 472: 29.21