HitPredict

Interactor 1: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Interactor 2: NECP1 (Q8NC96)
Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)
Gene: NECAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016192 - vesicle-mediated transport
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 275
+	Hs
		1241228 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		NECP1_HUMAN (1-275): 6.35e-158: 441: 100.00
+	Hs
		1241221 AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71		NECP1_HUMAN (1-275): 6.35e-158: 441: 100.00
+	Hs
		1241218 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		NECP1_HUMAN (1-275): 6.35e-158: 441: 100.00
+	Hs
		1315714 AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71		NECP2_HUMAN (4-275): 9.22e-141: 398: 61.96
+	Hs
		864109 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		NECP2_HUMAN (4-275): 9.22e-141: 398: 61.96
+	Hs
		1287510 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		NECP2_HUMAN (4-275): 9.22e-141: 398: 61.96