HitPredict

Interactor 1: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 530
+	Hs
		1270063 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269526 AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		902348 COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369240 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369303 COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370172 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		509310 AP2M1_MOUSE (1-138): 1.82e-41: 144: 15.22		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		487881 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59