HitPredict

Interactor 1: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Interactor 2: REPS1 (Q96D71)
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Gene: REPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 796
+	Hs
		1287459 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		REPS1_HUMAN (1-796): 2.33e-108: 351: 100.00
+	Hs
		864110 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		ITSN2_HUMAN (4-793): 2.76e-89: 310: 12.97
+	Hs
		1287515 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		ITSN2_HUMAN (4-793): 2.76e-89: 310: 12.97
+	Hs
		1244783 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		REPS2_HUMAN (4-796): 3.9e-87: 291: 32.23
+	Hs
		864112 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Hs
		1287519 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Hs
		880432 AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10		SYNRG_HUMAN (15-788): 4.39e-54: 205: 10.71
+	Hs
		1299173 AP1S3_HUMAN (1-142): 1.49e-49: 157: 42.96		SYNRG_HUMAN (15-788): 4.39e-54: 205: 10.71
+	Dm
		112646 Q9VDC3_DROME (1-142): 1.92e-46: 149: 95.78		M9NDL7_DROME (4-715): 5.2e-57: 212: 21.26
+	Dm
		112641 O62530_DROME (1-138): 2.63e-42: 146: 16.67		M9NDL7_DROME (4-715): 5.2e-57: 212: 21.26
+	Hs
		1357371 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		SYNRG_HUMAN (15-788): 4.39e-54: 205: 10.71
+	At
		1196569 AP2S_ARATH (1-142): 1.54e-44: 144: 61.27		Q9LM78_ARATH (9-536): 7.16e-51: 194: 15.79
+	Hs
		1349325 AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44		EHD2_HUMAN (256-370): 1e-40: 159: 33.91
+	Hs
		1287516 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		EHD2_HUMAN (256-370): 1e-40: 159: 33.91
+	Hs
		864076 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Hs
		787877 AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Hs
		1078888 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Hs
		787959 AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Ce
		725368 AP2M_CAEEL (1-138): 2.47e-43: 149: 15.94		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41