HitPredict

Interactor 1: ARNT (P53762)
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Gene: ARNT

Interactor 2: SIM1 (Q61045)
Single-minded homolog 1 (mSIM1)
Gene: SIM1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.831

Property	Details
Experiments	27782878, 20211142, 9020169
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~HLH, HLH~PAS, PAS~PAS, PAS~PAS_3, PAS~PAS_11, PAS_11~PAS_3
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0030154 - cell differentiation GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 791 Mm			1 765
+	Hs
		649084 ARNT_HUMAN (1-791): 0: 663: 91.28		SIM1_HUMAN (1-765): 0: 827: 96.61
+	Mm
		864793 ARNT_MOUSE (1-791): 0: 681: 100.00		SIM2_MOUSE (1-566): 3.1e-160: 481: 62.28
+	Hs
		649106 ARNT_HUMAN (1-791): 0: 663: 91.28		SIM2_HUMAN (1-660): 2.92e-165: 494: 54.91
+	Mm
		864794 ARNT_MOUSE (1-791): 0: 681: 100.00		HIF1A_MOUSE (2-559): 1.49e-138: 430: 30.55
+	Hs
		649123 ARNT_HUMAN (1-791): 0: 663: 91.28		HIF1A_HUMAN (2-713): 2.25e-140: 435: 26.82
+	Mm
		864790 ARNT_MOUSE (1-791): 0: 681: 100.00		EPAS1_MOUSE (2-639): 6.47e-130: 409: 22.45
+	Hs
		649033 ARNT_HUMAN (1-791): 0: 663: 91.28		ARNT_HUMAN (2-663): 5.61e-137: 425: 17.01
+	Mm
		101520 ARNT_MOUSE (1-791): 0: 681: 100.00		F8VQB2_MOUSE (2-652): 3.07e-128: 406: 28.01
+	Hs
		649150 ARNT_HUMAN (1-791): 0: 663: 91.28		EPAS1_HUMAN (2-632): 8.54e-131: 411: 21.91
+	Hs
		649132 ARNT_HUMAN (1-791): 0: 663: 91.28		NPAS3_HUMAN (2-655): 8.03e-127: 402: 28.06
+	Mm
		864789 ARNT_MOUSE (1-791): 0: 681: 100.00		NPAS1_MOUSE (2-502): 3.71e-119: 372: 30.98
+	Hs
		181499 ARNT_HUMAN (1-791): 0: 663: 91.28		CLOCK_HUMAN (2-664): 2.37e-120: 383: 18.16
+	Hs
		649148 ARNT_HUMAN (1-791): 0: 663: 91.28		NPAS1_HUMAN (2-491): 2.56e-120: 375: 30.91
+	Hs
		649052 ARNT_HUMAN (1-791): 0: 663: 91.28		AHR_HUMAN (5-694): 5.81e-108: 350: 17.85
+	Hs
		649117 ARNT_HUMAN (1-791): 0: 663: 91.28		NCOA2_HUMAN (4-537): 1.83e-103: 349: 18.90
+	Mm
		674910 ARNT_MOUSE (1-791): 0: 681: 100.00		AHR_MOUSE (5-710): 7.8e-101: 331: 18.96
+	Mm
		864796 ARNT_MOUSE (1-791): 0: 681: 100.00		NPAS4_MOUSE (1-598): 1.96e-99: 327: 21.46
+	Rn
		783942 ARNT_RAT (1-791): 0: 665: 93.88		AHR_RAT (5-645): 1.72e-102: 336: 19.14
+	Hs
		649131 ARNT_HUMAN (1-791): 0: 663: 91.28		NPAS4_HUMAN (1-598): 3.98e-99: 326: 21.46
+	Hs
		649149 ARNT_HUMAN (1-791): 0: 663: 91.28		NPAS2_HUMAN (2-695): 3.81e-97: 321: 16.80