HitPredict

Interactor 1: ARNT (P53762)
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Gene: ARNT

Interactor 2: HIF1A (Q61221)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein)
Gene: HIF1A

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.934

The method score is based on:

Property Details
Experiments 8816435, 26245371, 17277313, 20609350, 37793204
Identification Methods pull down, anti tag coimmunoprecipitation, molecular sieving, x-ray crystallography, electrophoretic mobility supershift assay, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~PAS, PAS~PAS, PAS~PAS_3, PAS~PAS_11, PAS_11~PAS_3
Common GO terms GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001666 - response to hypoxia
GO:0001892 - embryonic placenta development
GO:0003700 - DNA-binding transcription factor activity
and 13 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 791
Mm

1 836
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+ Rn
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Last updated: 15 Jul 2024