HitPredict

Interactor 1: MK12 (P53778)
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
Gene: MAPK12

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	24550280, 30126976
Identification Methods	affinity chromatography technology, phage display, anti tag coimmunoprecipitation, isothermal titration calorimetry, p8 filamentous phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 367 Hs			1 1630
+	Hs
		658937 MK01_HUMAN (13-357): 2.07e-141: 407: 40.63		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		647575 MK03_HUMAN (14-353): 2.84e-136: 394: 42.08		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		1082626 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Rn
		677771 MK01_RAT (13-357): 1.6e-141: 407: 40.63		DLG4_RAT (812-1187): 3.08e-49: 190: 22.42
+	Mm
		926414 MK01_MOUSE (13-357): 1.6e-141: 407: 40.63		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Rn
		1144013 MK12_RAT (1-367): 3.98e-157: 447: 93.73		DLG1_RAT (679-910): 1.87e-14: 80.9: 22.79
+	Mm
		140069 MK12_MOUSE (1-367): 1.68e-156: 445: 92.64		DLG1_MOUSE (678-910): 1.13e-14: 81.7: 22.13
+	Hs
		864822 MK12_HUMAN (1-367): 2.48e-155: 443: 100.00		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		864844 MK12_HUMAN (1-367): 2.48e-155: 443: 100.00		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Rn
		926488 MK01_RAT (13-357): 1.6e-141: 407: 40.63		DLG3_RAT (724-947): 3.57e-19: 96.3: 31.23
+	Mm
		814054 MK14_MOUSE (5-363): 2.06e-145: 417: 61.56		DLG1_MOUSE (678-910): 1.13e-14: 81.7: 22.13
+	Hs
		280030 MK09_HUMAN (9-366): 2.83e-108: 325: 45.46		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40