HitPredict

Interactor 1: MK12 (P53778)
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
Gene: MAPK12

Interactor 2: TAB1 (Q15750)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)
Gene: TAB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12429732
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PP2C~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 367 Hs			1 504
+	Hs
		1077876 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		TAB1_HUMAN (1-504): 0: 525: 100.00
+	Mm
		814056 MK14_MOUSE (5-363): 2.06e-145: 417: 61.56		TAB1_MOUSE (1-504): 2.7e-180: 517: 97.22
+	Hs
		1077875 MK11_HUMAN (1-364): 3.89e-141: 406: 62.36		TAB1_HUMAN (1-504): 0: 525: 100.00
+	Hs
		960096 CDK3_HUMAN (24-327): 1.53e-139: 400: 38.07		TAB1_HUMAN (1-504): 0: 525: 100.00
+	Rn
		88940 G3V617_RAT (5-363): 1.42e-145: 417: 61.56		D4A6C6_RAT (12-504): 1.95e-175: 504: 96.15
+	Hs
		800786 MK08_HUMAN (9-367): 3.51e-105: 317: 44.00		TAB1_HUMAN (1-504): 0: 525: 100.00
+	Hs
		728613 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		PPM1A_HUMAN (30-381): 4.24e-87: 274: 13.57
+	Hs
		273366 CDK2_HUMAN (24-317): 4.02e-147: 419: 36.00		PPM1B_HUMAN (30-381): 3.58e-83: 267: 13.65
+	Hs
		658816 MK01_HUMAN (13-357): 2.07e-141: 407: 40.63		PPM1A_HUMAN (30-381): 4.24e-87: 274: 13.57
+	Hs
		175390 MK11_HUMAN (1-364): 3.89e-141: 406: 62.36		PPM1D_HUMAN (3-397): 1.41e-73: 245: 16.35