HitPredict

Interactor 1: MK12 (P53778)
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
Gene: MAPK12

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 367 Hs			1 567
+	Mm
		140068 MK12_MOUSE (1-367): 1.68e-156: 445: 92.64		MK14_MOUSE (74-377): 3.21e-73: 239: 16.40
+	Hs
		625115 CDK2_HUMAN (24-317): 4.02e-147: 419: 36.00		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		625363 CDK2_HUMAN (24-317): 4.02e-147: 419: 36.00		CDK3_HUMAN (76-371): 9.13e-81: 257: 17.28
+	At
		1106290 MPK4_ARATH (10-355): 1.12e-143: 413: 43.59		MPK4_ARATH (82-401): 4.37e-78: 252: 15.24
+	Mm
		814036 MK14_MOUSE (5-363): 2.06e-145: 417: 61.56		MK14_MOUSE (74-377): 3.21e-73: 239: 16.40
+	Hs
		864845 MK12_HUMAN (1-367): 2.48e-155: 443: 100.00		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	At
		1259034 MPK16_ARATH (4-364): 5.53e-139: 408: 38.17		CIPKN_ARATH (271-565): 7.74e-68: 229: 13.18
+	At
		1105533 MPK4_ARATH (10-355): 1.12e-143: 413: 43.59		KSG6_ARATH (32-372): 2.07e-65: 220: 13.74
+	Hs
		658855 MK01_HUMAN (13-357): 2.07e-141: 407: 40.63		GSK3B_HUMAN (23-336): 1.58e-67: 226: 16.87
+	Hs
		1082619 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		864831 MK12_HUMAN (1-367): 2.48e-155: 443: 100.00		MK11_HUMAN (63-259): 8.91e-43: 158: 23.42
+	At
		1105932 MPK4_ARATH (10-355): 1.12e-143: 413: 43.59		MPK1_ARATH (57-258): 5.52e-49: 175: 19.62
+	Hs
		1082557 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		MK14_HUMAN (66-259): 1.61e-45: 165: 21.78
+	Hs
		647591 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		MK03_HUMAN (65-267): 6e-45: 165: 21.60
+	Hs
		1078188 MK14_HUMAN (5-363): 4.78e-145: 416: 61.56		MK11_HUMAN (63-259): 8.91e-43: 158: 23.42
+	Mm
		814061 MK14_MOUSE (5-363): 2.06e-145: 417: 61.56		MK11_MOUSE (63-259): 1.69e-42: 157: 23.42
+	Hs
		647474 MK01_HUMAN (13-357): 2.07e-141: 407: 40.63		MK03_HUMAN (65-267): 6e-45: 165: 21.60
+	Rn
		600373 MK01_RAT (13-357): 1.6e-141: 407: 40.63		MK03_RAT (75-267): 1.43e-44: 164: 20.90