HitPredict

Interactor 1: MK10 (P53779)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Gene: MAPK10

Interactor 2: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 464 Hs			1 535
+	Hs
		864873 MK10_HUMAN (1-464): 0: 517: 100.00		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		800744 MK08_HUMAN (39-464): 5.15e-162: 465: 90.87		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		800722 MK08_HUMAN (39-464): 5.15e-162: 465: 90.87		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		573163 MK08_HUMAN (39-464): 5.15e-162: 465: 90.87		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		625579 CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		625349 CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		173879 MK13_HUMAN (43-411): 3.49e-133: 390: 45.55		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		625228 CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		173861 MK13_HUMAN (43-411): 3.49e-133: 390: 45.55		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Sc
		691072 HOG1_YEAST (43-403): 2.61e-131: 388: 37.91		TCPH_YEAST (1-532): 0: 559: 33.09
+	Hs
		573132 CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		625220 CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		173858 MK13_HUMAN (43-411): 3.49e-133: 390: 45.55		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Sc
		691051 HOG1_YEAST (43-403): 2.61e-131: 388: 37.91		TCPG_YEAST (5-528): 0: 537: 28.33
+	Rn
		600431 MK03_RAT (58-397): 3.58e-85: 268: 42.41		TCPB_RAT (1-535): 0: 584: 97.76
+	Rn
		600467 MK03_RAT (58-397): 3.58e-85: 268: 42.41		TCPG_RAT (3-532): 0: 565: 28.89
+	Rn
		600455 MK03_RAT (58-397): 3.58e-85: 268: 42.41		TCPE_RAT (8-524): 0: 554: 33.02
+	Rn
		600336 MK03_RAT (58-397): 3.58e-85: 268: 42.41		TCPA_RAT (7-532): 4.33e-83: 270: 34.85