HitPredict

Interactor 1: TTC3 (P53804)
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
Gene: TTC3

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2025 Hs			1 522
+	Hs
		297117 TOM70_HUMAN (224-631): 8.39e-55: 205: 13.83		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		685136 STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		536866 TGO1_HUMAN (1104-1863): 1.22e-83: 308: 14.29		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		584960 DCTN1_HUMAN (1227-1708): 2.17e-62: 237: 13.50		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		129535 STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1019301 DCTN1_HUMAN (1227-1708): 2.17e-62: 237: 13.50		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		175164 OGT1_HUMAN (81-443): 8.81e-20: 98.9: 10.24		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		585003 DZIP3_HUMAN (522-739): 1.71e-38: 160: 27.03		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		175109 OGT1_HUMAN (81-443): 8.81e-20: 98.9: 10.24		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		174596 OGT1_HUMAN (81-443): 8.81e-20: 98.9: 10.24		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		213639 SGTA_HUMAN (220-333): 1.13e-24: 108: 29.83		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		1052745 DNJC7_HUMAN (133-395): 1.18e-09: 65: 16.23		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		1205101 DZIP3_HUMAN (522-739): 1.71e-38: 160: 27.03		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		537012 DNJC7_HUMAN (133-395): 1.18e-09: 65: 16.23		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		174976 OGT1_HUMAN (81-443): 8.81e-20: 98.9: 10.24		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26