HitPredict

Interactor 1: SMTN (P53814)
Smoothelin
Gene: SMTN

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 917 Hs			1 530
+	Hs
		521591 ACTN1_HUMAN (676-916): 2.64e-71: 255: 23.64		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		993279 ACTN3_HUMAN (690-916): 1.28e-70: 253: 22.95		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211633 ACTN4_HUMAN (661-916): 5.31e-69: 249: 20.51		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1068618 PLEC_HUMAN (613-916): 9.93e-67: 246: 18.52		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		164649 SPTN2_HUMAN (669-917): 1.01e-66: 246: 22.34		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269937 MACF1_HUMAN (620-914): 1.07e-63: 237: 20.95		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1232241 EH1L1_HUMAN (622-912): 5.67e-63: 234: 25.43		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368893 ACTN1_HUMAN (676-916): 2.64e-71: 255: 23.64		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369420 SPTB2_HUMAN (664-917): 4.67e-68: 250: 22.66		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		211456 ACTN4_HUMAN (661-916): 5.31e-69: 249: 20.51		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369641 PLEC_HUMAN (613-916): 9.93e-67: 246: 18.52		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370715 MACF1_HUMAN (620-914): 1.07e-63: 237: 20.95		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		1142708 SMTN_MOUSE (1-917): 5.91e-81: 283: 79.78		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		320227 SPTN4_HUMAN (643-917): 3.39e-71: 260: 21.07		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		510045 MACF1_HUMAN (620-914): 1.07e-63: 237: 20.95		ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65
+	Hs
		521532 ACTN1_HUMAN (676-916): 2.64e-71: 255: 23.64		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		211472 ACTN4_HUMAN (661-916): 5.31e-69: 249: 20.51		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		377488 EH1L1_HUMAN (622-912): 5.67e-63: 234: 25.43		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		580490 ACTN2_MOUSE (670-916): 1.26e-70: 253: 21.59		ANDR_MOUSE (149-407): 1.53e-38: 152: 33.70
+	Hs
		211471 ACTN4_HUMAN (661-916): 5.31e-69: 249: 20.51		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59