HitPredict

Interactor 1: ICLN (P54105)
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)
Gene: CLNS1A

Interactor 2: LSM6 (P62312)
U6 snRNA-associated Sm-like protein LSm6
Gene: LSM6

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	28514442, 33961781, 22365833, 25416956, 32296183, 35271311, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LSM~Voldacs
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 237 Hs			1 80
+	Hs
		867495 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		LSM4_HUMAN (8-80): 5.81e-33: 112: 27.03
+	Hs
		867405 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57
+	Hs
		867492 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		LSM2_HUMAN (10-80): 3.6e-20: 78.4: 27.03
+	Hs
		867411 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		SMD3_HUMAN (8-77): 5.73e-19: 76.1: 21.43
+	Ce
		107955 G5EFZ5_CAEEL (12-200): 1.7e-57: 183: 33.16		SMD3_CAEEL (8-77): 4.3e-19: 76.8: 25.71
+	Ce
		107977 G5EG22_CAEEL (12-200): 2.28e-53: 173: 29.58		SMD3_CAEEL (8-77): 4.3e-19: 76.8: 25.71
+	Dm
		55530 ICLN_DROME (12-193): 1.41e-52: 171: 27.36		Q9VTW6_DROME (10-80): 5.28e-20: 78: 27.03