HitPredict

Interactor 1: BLM (P54132)
RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)
Gene: BLM

Interactor 2: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.761

The method score is based on:

Property Details
Experiments 11919194
Identification Methods affinity chromatography technology, pull down, enzyme linked immunosorbent assay, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~DEAD, DEAD~Helicase_C, DEAD~HRDC, DEAD~RecQ_Zn_bind, Helicase_C~Helicase_C, HRDC~Helicase_C, Helicase_C~RecQ_Zn_bind, Helicase_C~RQC, DNA_pol_A_exo1~HRDC, HRDC~HRDC, RQC~RecQ_Zn_bind, RQC~RQC
Common GO terms GO:0000400 - four-way junction DNA binding
GO:0000403 - Y-form DNA binding
GO:0000405 - bubble DNA binding
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
and 28 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1417
Hs

1 1432
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+ At

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Last updated: 15 Jul 2024