HitPredict

Interactor 1: HIRA (P54198)
Protein HIRA (TUP1-like enhancer of split protein 1)
Gene: HIRA

Interactor 2: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0031491 - nucleosome binding GO:0042393 - histone binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1017 Hs			1 425
+	Hs
		867861 HIRA_HUMAN (1-1017): 0: 779: 100.00		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Gg
		945615 HIRA_CHICK (1-1014): 0: 734: 85.11		RBBP4_CHICK (1-209): 1.67e-39: 148: 12.72
+	Sc
		532830 CAC2_YEAST (1-423): 7.16e-88: 292: 20.29		MSI1_YEAST (16-409): 1.94e-76: 245: 29.15
+	Hs
		997700 CAF1B_HUMAN (1-520): 2.28e-89: 299: 23.15		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		793026 KTNB1_HUMAN (2-271): 9.5e-41: 162: 22.59		LIS1_HUMAN (8-257): 7.41e-58: 196: 12.77
+	Ce
		954090 LIS1_CAEEL (159-451): 4e-48: 178: 14.24		LIN53_CAEEL (1-209): 6.74e-42: 154: 14.16
+	Hs
		792949 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		LIS1_HUMAN (8-257): 7.41e-58: 196: 12.77
+	Hs
		903349 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		WDR5B_HUMAN (1-254): 1.38e-58: 196: 14.83
+	Hs
		929640 KTNB1_HUMAN (2-271): 9.5e-41: 162: 22.59		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		903551 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		NLE1_HUMAN (202-424): 3.82e-45: 164: 21.15
+	Hs
		1346954 NLE1_HUMAN (724-858): 6.84e-16: 83.8: 9.03		NLE1_HUMAN (202-424): 3.82e-45: 164: 21.15
+	Dm
		1358845 WDS_DROME (359-647): 5.17e-18: 88.8: 7.61		WDS_DROME (212-422): 1.48e-43: 157: 19.91
+	Hs
		903171 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		903109 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		929692 NLE1_HUMAN (724-858): 6.84e-16: 83.8: 9.03		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		903077 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		903471 WDR5_HUMAN (362-647): 5.91e-18: 88.4: 8.39		GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47
+	Hs
		1202778 WDR5B_HUMAN (535-854): 7.11e-18: 88: 10.81		GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47