HitPredict

Interactor 1: ATX3 (P54252)
Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)
Gene: ATXN3

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	30455355, 10915768, 19843543, 16713569, 16712842
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Josephin~ubiquitin, UIM~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006289 - nucleotide-excision repair GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 361 Hs			1 409
+	Hs
		868092 ATX3_HUMAN (1-361): 0: 508: 100.00		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		872169 Q4VBR4_HUMAN (1-361): 3.65e-178: 500: 97.03		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		868368 ATX3_HUMAN (1-361): 0: 508: 100.00		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Hs
		474967 ATX3_HUMAN (1-361): 0: 508: 100.00		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Mm
		476980 ATX3_MOUSE (1-361): 4.44e-173: 487: 85.08		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67