HitPredict

Interactor 1: ATX3 (P54252)
Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)
Gene: ATXN3

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22626734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 361 Hs			1 353
+	Hs
		868321 ATX3_HUMAN (1-361): 0: 508: 100.00		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		868322 ATX3_HUMAN (1-361): 0: 508: 100.00		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		1282038 ATX3L_HUMAN (1-361): 2.05e-156: 445: 69.81		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		1317440 ATX3L_HUMAN (1-361): 2.05e-156: 445: 69.81		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		1317509 ATX3L_HUMAN (1-361): 2.05e-156: 445: 69.81		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		868234 ATX3_HUMAN (1-361): 0: 508: 100.00		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		1065233 JOS1_HUMAN (4-169): 2.79e-54: 179: 25.28		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		1065240 JOS1_HUMAN (4-169): 2.79e-54: 179: 25.28		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		536837 JOS1_HUMAN (4-169): 2.79e-54: 179: 25.28		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1065241 JOS1_HUMAN (4-169): 2.79e-54: 179: 25.28		TRIM1_HUMAN (14-345): 3.61e-59: 205: 22.00