HitPredict

Interactor 1: ATX3 (P54252)
Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)
Gene: ATXN3

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

The method score is based on:

Property	Details
Experiments	29111377, 21855799, 20943656, 23696636, 32401531, 21625540, 19153604
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process and 7 others more... GO:0006515 - protein quality control for misfolded or incompletely synthesized proteins GO:0031625 - ubiquitin protein ligase binding GO:0034605 - cellular response to heat GO:0042405 - nuclear inclusion body GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0071218 - cellular response to misfolded protein GO:1904294 - positive regulation of ERAD pathway
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	361
Hs

1	303

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024