HitPredict

Interactor 1: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 815 Hs			1 937
+	Mm
		869253 ATX1_MOUSE (1-815): 0: 1271: 86.89		AP2B1_MOUSE (1-937): 0: 926: 99.89
+	Mm
		193235 ATX1_MOUSE (1-815): 0: 1271: 86.89		AP1B1_MOUSE (1-937): 0: 883: 83.88
+	Hs
		212609 ATX1_HUMAN (1-815): 0: 1349: 100.00		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Mm
		567519 ATX1_MOUSE (1-815): 0: 1271: 86.89		AP2A2_MOUSE (11-932): 0: 596: 16.50
+	Mm
		869276 ATX1_MOUSE (1-815): 0: 1271: 86.89		COPB_MOUSE (8-927): 0: 559: 12.47
+	Mm
		869329 ATX1_MOUSE (1-815): 0: 1271: 86.89		AP3B1_MOUSE (8-594): 1.39e-176: 543: 28.12
+	Hs
		276355 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		AP1G2_HUMAN (11-698): 4e-162: 496: 14.73