HitPredict

Interactor 1: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 815 Hs			1 197
+	Hs
		868441 ATX1_HUMAN (1-815): 0: 1349: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		868440 ATX1_HUMAN (1-815): 0: 1349: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		473498 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		473503 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00