HitPredict

Interactor 1: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Interactor 2: SRBP2 (Q12772)
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Gene: SREBF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 815 Hs			1 1141
+	Hs
		738951 ATX1_HUMAN (1-815): 0: 1349: 100.00		SRBP1_HUMAN (1-1141): 0: 870: 43.72
+	Hs
		868656 ATX1_HUMAN (1-815): 0: 1349: 100.00		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Mm
		101431 ATX1_MOUSE (1-815): 0: 1271: 86.89		F8VPR5_MOUSE (4-430): 3.34e-13: 76.9: 13.52
+	Mm
		868951 ATX1_MOUSE (1-815): 0: 1271: 86.89		SC31A_MOUSE (143-486): 1.88e-10: 67.7: 10.89
+	Mm
		223234 ATX1_MOUSE (1-815): 0: 1271: 86.89		SPT5H_MOUSE (136-326): 2.18e-10: 67.3: 9.90
+	Hs
		473481 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		SRBP1_HUMAN (1-1141): 0: 870: 43.72