HitPredict

Interactor 1: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Interactor 2: KLF5 (Q13887)
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)
Gene: KLF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35140242, 32814053
Identification Methods	proximity labelling technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 815 Hs			1 457
+	Hs
		868824 ATX1_HUMAN (1-815): 0: 1349: 100.00		KLF12_HUMAN (353-455): 4.09e-44: 160: 76.92
+	Hs
		316831 ATX1_HUMAN (1-815): 0: 1349: 100.00		KLF8_HUMAN (366-455): 4.48e-40: 149: 78.89
+	Hs
		868399 ATX1_HUMAN (1-815): 0: 1349: 100.00		KLF3_HUMAN (308-455): 2.48e-37: 141: 59.33
+	Hs
		157882 ATX1_HUMAN (1-815): 0: 1349: 100.00		KLF11_HUMAN (366-455): 1.77e-29: 122: 65.56
+	Hs
		473511 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		KLF5_HUMAN (1-457): 3.24e-124: 370: 100.00
+	Hs
		473493 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		KLF3_HUMAN (308-455): 2.48e-37: 141: 59.33
+	Hs
		473559 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		KLF16_HUMAN (373-455): 1.97e-30: 120: 63.86
+	Dm
		1215575 Q9W3V7_DROME (574-685): 5.39e-60: 205: 44.64		Q8IRM5_DROME (367-455): 4.69e-28: 118: 64.05
+	Dm
		66094 Q9W3V7_DROME (574-685): 5.39e-60: 205: 44.64		A8JUN6_DROME (367-455): 1.91e-26: 114: 64.05