HitPredict

Interactor 1: MLC2 (P54357)
Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain)
Gene: Mlc-c

Interactor 2: MYO7A (Q9V3Z6)
Myosin-VIIa (DmVIIa) (Protein crinkled)
Gene: ck

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16917818
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_6~IQ, EF-hand_6~Myosin_head, EF-hand_7~IQ, EF-hand_7~Myosin_head
Common GO terms	GO:0005829 - cytosol GO:0030048 - actin filament-based movement GO:0031477 - myosin VII complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 147 Dm			1 2167
+	Dm
		906697 CALM_DROME (3-146): 1.12e-46: 149: 43.45		MYO7A_DROME (1-2167): 0: 1854: 100.00
+	Hs
		484218 CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45		MYO5B_HUMAN (3-1413): 0: 986: 25.25
+	Sc
		420223 CALM_YEAST (2-146): 1.14e-45: 147: 37.42		MYO2_YEAST (62-925): 6.17e-163: 546: 37.22
+	Hs
		214479 CALM1_HUMAN (3-146): 3.02e-47: 151: 43.45		MYO1B_HUMAN (64-824): 1.17e-164: 540: 38.68
+	Hs
		214480 CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45		MYO1B_HUMAN (64-824): 1.17e-164: 540: 38.68
+	Hs
		484202 CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45		MYO10_HUMAN (1706-2166): 5.18e-31: 136: 19.17
+	Hs
		648611 CALL3_HUMAN (3-146): 5.6e-44: 143: 41.38		MYO10_HUMAN (1706-2166): 5.18e-31: 136: 19.17
+	Hs
		538643 MYL6B_HUMAN (3-146): 1.59e-47: 154: 53.38		MYH10_HUMAN (795-1177): 8.04e-14: 79.7: 11.19
+	Hs
		538642 MYL6B_HUMAN (3-146): 1.59e-47: 154: 53.38		MYH9_HUMAN (673-1104): 7.08e-13: 76.7: 7.60
+	Hs
		725124 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH10_HUMAN (795-1177): 8.04e-14: 79.7: 11.19
+	Hs
		724737 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH9_HUMAN (673-1104): 7.08e-13: 76.7: 7.60
+	Hs
		728458 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH11_HUMAN (677-1094): 8.31e-13: 76.7: 11.19
+	Hs
		409452 MYL1_HUMAN (4-146): 3.1e-42: 140: 53.06		MYH10_HUMAN (795-1177): 8.04e-14: 79.7: 11.19
+	Hs
		648467 CALL3_HUMAN (3-146): 5.6e-44: 143: 41.38		MYH9_HUMAN (673-1104): 7.08e-13: 76.7: 7.60
+	Hs
		484206 CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45		MYO5C_HUMAN (983-1482): 2.74e-10: 68.3: 8.11
+	Hs
		441666 MYL3_HUMAN (4-146): 8.71e-40: 134: 48.99		MYH10_HUMAN (795-1177): 8.04e-14: 79.7: 11.19
+	Hs
		441665 MYL3_HUMAN (4-146): 8.71e-40: 134: 48.99		MYH9_HUMAN (673-1104): 7.08e-13: 76.7: 7.60